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The incidence of liver hemangiomas and hemangiosarcomas was significantly increased in one mouse study in female mice dosed at 8 mg/kg/day (2 times the maximum recommended human daily oral dose on a mg/m basis). These tumors were not increased in another mouse study in females dosed at 10 or 30/20 mg/kg/day (2-5 times the maximum recommended human daily oral dose on a mg/m basis); in this study, there was a high incidence of early mortalities in males of the 30/20 mg/kg/day group. The incidence of mammary gland adenomas and adenocarcinomas was significantly increased in female mice dosed at /=2 mg/kg/day and in female rats dosed at /=4 mg/kg/day (0.5 and 2 times the maximum recommended human daily oral dose on a mg/m basis, respectively).

Zyprexa Overdose

US residents can call the US national poison hotline at 1-800-222-1222. Parturition in rats was not affected by olanzapine. Consult your doctor for more details. This database includes: (1) 2500 patients who participated in multiple-dose oral olanzapine premarketing trials in schizophrenia and Alzheimer's disease representing approximately 1122 patient-years of exposure as of February 14, 1995; (2) 182 patients who participated in oral olanzapine premarketing bipolar mania trials representing approximately 66 patient-years of exposure; (3) 191 patients who participated in an oral olanzapine trial of patients having various psychiatric symptoms in association with Alzheimer's disease representing approximately 29 patient-years of exposure; (4) 5788 patients from 88 additional oral olanzapine clinical trials as of December 31, 2001; and (5) 722 patients who participated in intramuscular olanzapine for injection premarketing trials in agitated patients with schizophrenia, Bipolar I Disorder (manic or mixed episodes), or dementia.

Zyprexa Missed Dose

If overdose is suspected, contact your local poison control center or emergency room immediately. Laboratory and/or medical tests (e. g. , fasting blood sugar-FBS, weight, blood pressure, blood cholesterol/triglyceride levels, liver function tests) should be performed periodically to monitor your progress or check for side effects. In addition, information from the premarketing 6-week clinical study database for olanzapine in combination with lithium or valproate, consisting of 224 patients who participated in bipolar mania trials with approximately 22 patient-years of exposure, is included below. The conditions and duration of treatment with olanzapine varied greatly and included (in overlapping categories) open-label and double-blind phases of studies, inpatients and outpatients, fixed-dose and dose-titration studies, and short-term or longer-term exposure.

Zyprexa Notes

If any of these effects persist or worsen, notify your doctor or pharmacist promptly. To minimize dizziness or fainting, stand up slowly when arising from a seated or lying position; especially when you first start using this medication. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor immediately if any of these serious side effects occur: fast heartbeat ankle/leg swelling agitation confusion restlessness weakness difficulty speaking numbness or tingling of hands or feet trouble walking (abnormal gait) painful menstrual periods pink urine tremor Tell your doctor immediately if any of these unlikely but serious side effects occur: yellowing of the eyes or skin painful urination other eye problems seizures difficulty swallowing Seek immediate medical attention if any of these unlikely but serious side effects occur: chest pain weakness on one side of the body sudden vision changes headache This drug may infrequently make your blood sugar level rise, which can cause or worsen diabetes.

Zyprexa Storage

Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets. In premarketing trials involving more than 3100 patients and/or normal subjects, accidental or intentional acute overdosage of olanzapine was identified in 67 patients. In the patient taking the largest identified amount, 300 mg, the only symptoms reported were drowsiness and slurred speech. In the limited number of patients who were evaluated in hospitals, including the patient taking 300 mg, there were no observations indicating an adverse change in laboratory analytes or ECG

Any knowledge of nearly passing out when standing up rapidly as a side affect of Zyprexa?